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Eliminating Spam

A real solution to spam is defined as one which decreases spam to the point where it can easily be filtered manually while only decreasing non-spam by a small amount.

H: Have your machine highlight messages you want to read.
$: Charge senders and possibly refund them later.
C: Make senders provide a proof of work, like computing a partial hash.
T: Make senders provide a proof of humanness, like a describing a distorted image.

H causes the least disruptions but is difficult to do well. $ is the most effective but requires a new mail system and a new attitude. C is less effective but requires less disruption. T requires more disruption but is more effective.

I'm interested in hearing about other real solutions. More on bogus solutions is at Comments on spam.